New to Trulicity?
About to start a new dose?

Here are 3 important things you should know when starting once-weekly Trulicity.

If eligible, you may be able to save on your prescription, regardless of the dose you are prescribed.

For patients with coverage for Trulicity through their commercial drug insurance coverage: Offer good until 03/31/2022 for up to 18 months of Trulicity. Patients must activate the savings card by 3/31/2021. Patients must have coverage for Trulicity through their commercial drug insurance coverage to pay as little as $25 for 4 pens of Trulicity. Offer subject to a monthly cap of $150 and a separate annual cap of $1800. For patients with commercial drug insurance who do not have coverage for Trulicity 3.0mg/4.5mg through their commercial drug insurance: Offer good until 3/31/2022 for up to 6 fills of Trulicity 3.0mg or 4.5mg. Patients must activate the savings card by 3/31/2021. Patients must have commercial drug insurance and not have coverage for Trulicity 3.0mg/4.5mg to pay as little as $25 for 4 pens of Trulicity 3.0mg or 4.5mg. Offer subject to a monthly cap of wholesale acquisition cost plus usual and customary pharmacy charges and a separate annual cap set at Lilly’s sole discretion. For all patients utilizing the Trulicity Savings Card: Patient is responsible for any applicable taxes, fees, or amounts exceeding monthly or annual caps. This offer is invalid for patients without commercial drug insurance or whose prescription claims for Trulicity are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DoD, VA, TRICARE^®/CHAMPUS, or any state patient or pharmaceutical assistance program. Offer void where prohibited by law and subject to change or discontinue without notice. Card activation is required. Subject to additional terms and conditions, which can be found at trulicity.com/savings-resources/savingcards/.

Get a Savings Card

Watch this step-by-step video that walks you through how to use your Trulicity Pen. Each pen contains one dose with no need to measure or mix anything.

It works with the click of a button.*

Uncap the pen

Place and unlock

Press and hold

Each dose comes in its own easy-to-use^† pen, so you can continue to have the same experience with once-weekly Trulicity, regardless of the dose you’ve been prescribed.

*Read the Instructions for Use included with your pen.

†In a study, 94% of people who used the Trulicity Pen found it easy to use.

Everyone’s experience is different, but there are some changes that you might notice when you take Trulicity. The most common side effects with Trulicity are:

Nausea
Diarrhea
Vomiting
Abdominal pain
Decreased appetite

Nausea happens most often when first starting Trulicity.

In studies, 8%-29% using Trulicity experienced some nausea, which typically occurred during the first 2-3 days after they took their first dose. Nausea generally subsided after the first 2 weeks, but some people experienced nausea with Trulicity beyond their second week of treatment. Less than 2% needed to stop taking Trulicity because of nausea.*

When you increase your dose of Trulicity, you might experience nausea. With the higher dose options, about 16% of people experienced nausea and about 1% of people needed to stop taking Trulicity because of it.

The most common adverse reactions experienced with Trulicity are nausea, diarrhea, vomiting, abdominal pain, decreased appetite, indigestion and fatigue. The rates of nausea, vomiting and diarrhea, while numerically higher in each of the higher dulaglutide groups compared with the 1.5 mg group were similar between between the dulaglutide 3.0 mg and 4.5 mg groups in a clinical trial.*

Talk with your healthcare provider about any side effects you experience.

If you experience nausea, talk to your doctor. In the meantime, you may find the following tips helpful.

Eat smaller meals — try splitting your three daily meals into four or more smaller ones
Stop eating when you feel full
Avoid fried or fatty foods
Try eating bland foods like toast, crackers, or rice

*In studies, GI side effects were more common in people taking Trulicity than people taking placebo, and people taking Trulicity were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure). Trulicity may cause severe stomach problems.

Additional information as you're getting started

Trulicity is taken just once a week. You can take Trulicity any time during this day, with or without meals. So, start by picking the best day for you and mark it as your Trulicity Day.

Do your best to stick to the same day every week.

If you'd like to change your Trulicity Day, you can. If it's been more than 3 days since your last dose, you can switch. If it's been fewer than 3 days since your last dose, wait until the following week to take the dose on your new Trulicity Day.

*Do not take 2 doses of Trulicity within 3 days of each other.

More dose options. More treatment possibilities.

Trulicity has 4 dose options to better fit your type 2 diabetes needs. And because each dose comes in the easy-to-use* pen, you can continue to have the same experience with once-weekly Trulicity, regardless of the dose you’ve been prescribed.

*In a study, 94% of people said it was easy to use.

Read the Instructions for Use included with your pen.

Choosing your injection site

Your doctor can help you choose the areas on your body that are best to use Trulicity. Be sure to use a different spot every time and do not overuse any one. Suggested places to use Trulicity are your upper arm, abdomen, or thigh (see diagram below).

How Trulicity can help

Starts acting from the first dose

Trulicity starts lowering your blood sugar from the first dose by helping your body release the insulin it’s still making.

Blood sugar levels

In studies, Trulicity has been proven to lower blood sugar levels. People taking Trulicity may notice better blood sugar numbers before eating in the morning (fasting blood sugar).

A1C reduction

Trulicity may offer lasting A1C improvements. In a study, some Trulicity users saw a significant improvement when their A1C was measured after 6 months, and it was still improved after they had been taking Trulicity for 1 year.

Majority of people reached an A1C under 7%.

Studies ranging between 24-36 weeks
59% to 60% for 0.75 mg Trulicity
50% to 68% for 1.5 mg Trulicity
56% for 3.0 mg Trulicity
62%for 4.5 mg Trulicity

If you have trouble meeting your A1C goal, talk with your doctor. You may need to adjust your medication, diet or exercise routine.

Weight Change

Trulicity is not a weight loss drug. Individual results may vary. People lost up to 10 lbs. While many people in clinical trials lost weight, some did gain weight.

In one study, many people lost some weight over the course of 6 months, and they were able to keep if off for the remainder of the study.

In clinical trials, weight change in adults ranges from +0.4 lbs (0.75 mg) to -10.1 lbs (4.5 mg).

Store your pen in the refrigerator, but do NOT freeze your pen.
If you decide to travel with your Trulicity pens, you can keep them at room temperature (below 86°F, 30°C) for up to 14 days.

[Icon of a house with thecopy: Trulicity Pen may be stored at room temp for 14 days]

Dispose safely after use

Even though there’s no need to handle or see the needle in your Trulicity Pen, it’s important to safely dispose of your Trulicity Pens in a sharps container. If you don't have a sharps container, be sure to dispose the Trulicity pen in a puncture-resistant container with a closable lid -- like an empty plastic laundry detergent bottle, or a coffee can.

Keep container out of reach from children and pets.

Refer to regulations in your area for how to dispose of the container properly.

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The Lilly Answers Center

If you have additional questions, call The Lilly Answers Center at 1‑844‑TRU‑INFO (1‑844‑878‑4636). Although we won't be able to replace the advice of your healthcare provider, we'll do our best to help you.

Purpose and Safety Summary
WARNING: POTENTIAL RISK OF THYROID TUMORS INCLUDING THYROID CANCER

PURPOSE AND SAFETY SUMMARY WITH WARNINGS

Important Facts About Trulicity^® (Trῡ-li-si-tee). It is also known as dulaglutide.

Trulicity is a prescription medicine for adults with type 2 diabetes used to improve blood sugar (glucose) and used to reduce the risk of major cardiovascular events (problems having to do with the heart and blood vessels) such as death, heart attack, or stroke in people who have heart disease or multiple cardiovascular risk factors.

Trulicity is given through an injection (needle). You take it once a week by injecting it under the skin of your stomach, thigh, or upper arm. Use Trulicity together with the diet and exercise that your doctor recommends.

Do not use Trulicity if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
Do not use Trulicity if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Do not use Trulicity if you are allergic to dulaglutide or other ingredients in Trulicity.

Ask your doctor how to recognize the serious side effects below and what to do if you think you have one:

Inflamed pancreas (pancreatitis). Stop using Trulicity and call your healthcare provider right away if you have severe pain in your stomach area (abdomen), with or without vomiting, that will not go away. You may feel the pain from your abdomen to your back.

Changes in vision. Tell your healthcare provider if you have changes in your eyesight (vision) during treatment with Trulicity

Low blood sugar (hypoglycemia). Signs and symptoms of low blood sugar may include dizziness or light-headedness, confusion or drowsiness, headache, blurred vision, slurred speech, fast heartbeat, sweating, hunger, shakiness, feeling jittery, weakness, anxiety, irritability, or mood changes.

Serious allergic reactions. Stop using Trulicity and get medical help right away if you have any symptoms of a serious allergic reaction which may include: swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Acute kidney injury. In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration). This may cause kidney problems to get worse.

Severe stomach problems. Trulicity may cause stomach problems, which could be severe.

The most common side effects of Trulicity include nausea, diarrhea, vomiting, abdominal pain and decreased appetite, indigestion, and fatigue.

These are not all the possible side effects of Trulicity.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Your healthcare provider should show you how to use Trulicity before you use it for the first time.
Before you use Trulicity, talk to your doctor about low blood sugar and how to manage it.

Do you have other medical conditions, including problems with your pancreas, kidneys, liver, or stomach, or have a history of diabetic retinopathy (vision problems related to diabetes)?
Do you take other diabetes medicines, such as insulin or sulfonylureas?
Do you take any other prescription medicines or over-the-counter drugs, vitamins or herbs?

You are pregnant or plan to become pregnant or breastfeeding or plan to breastfeed.
You have type 1 diabetes.
You have or have had an inflamed pancreas (pancreatitis).
You have severe intestinal or stomach problems, such as slowed emptying or problems with digesting food.
You are a child under 18 years old.

Read the Instructions for Use that come with Trulicity.
Use Trulicity exactly as your doctor says.
Do not share your Trulicity pen, syringe or needles with another person.
Do not give Trulicity to other people.
If you take too much Trulicity, call your healthcare provider or seek medical advice promptly.

For more information, call 1-844-TRU-INFO (1-844-878-4636) or please see full Prescribing Information, including Boxed Warning about possible thyroid tumors including thyroid cancer, Medication Guide and Instructions for Use.

This summary provides basic information about Trulicity but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Trulicity and how to take it. Your doctor is the best person to help you decide if Trulicity is right for you.

Trulicity^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

DG CON HL BS SEP 2020