New to Trulicity?
About to start a new dose?

Here are 3 important things you should know when starting once-weekly Trulicity.

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Getting access to savings

If eligible, you may be able to save on your prescription, regardless of the dose you are prescribed.

[Icon of Trulicity Savings Card with copy: Pay as little as $25 with the Trulicity Savings Card*]

Offer good until 12/31/2022. Patients must first use their card by 12/31/2021. Covered benefit to pay as little as $25 a month for up to 12 months of Trulicity. Offer subject to a monthly cap of up to $150 and a separate annual cap of $1,800. Non-covered benefit to pay as little as $25 a month for up to 12 months of Trulicity. Non-covered offer subject to a monthly cap of wholesale acquisition cost plus usual and customary pharmacy charges and a separate annual cap. Patient is responsible for any applicable taxes, fees, or amounts exceeding monthly or annual caps. This offer is invalid for patients without commercial drug insurance or those whose prescription claims are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare PartD, Medigap, DoD, VA, TRICARE®/CHAMPUS, or any state patient or pharmaceutical assistance program. Offer void where prohibited by law and subject to change or discontinue without notice. Card activation is required. Subject to additional terms and conditions, which can be found at

Get a Savings Card
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Using the Trulicity Pen

Watch this step-by-step video that walks you through how to use your Trulicity Pen. Each pen contains one dose with no need to measure or mix anything.


It works with the click of a button.*

Uncap the pen
Place and unlock
Press and hold

Each dose comes in its own easy-to-use pen, so you can continue to have the same experience with once-weekly Trulicity, regardless of the dose you’ve been prescribed.

*Read the Instructions for Use included with your pen.

†In a study, 94% of people who used the Trulicity Pen found it easy to use.

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Managing side effects

Everyone’s experience is different, but there are some changes that you might notice when you take Trulicity. The most common side effects with Trulicity are:

  • Nausea
  • Diarrhea
  • Vomiting
  • Abdominal pain
  • Decreased appetite

Nausea happens most often when first starting Trulicity.

In studies, 8%-29% using Trulicity experienced some nausea, which typically occurred during the first 2-3 days after they took their first dose. Nausea generally subsided after the first 2 weeks, but some people experienced nausea with Trulicity beyond their second week of treatment. Less than 2% needed to stop taking Trulicity because of nausea.*

When you increase your dose of Trulicity, you might experience nausea. With the higher dose options, about 16% of people experienced nausea and about 1% of people needed to stop taking Trulicity because of it.

The most common adverse reactions experienced with Trulicity are nausea, diarrhea, vomiting, abdominal pain, decreased appetite, indigestion and fatigue. The rates of nausea, vomiting and diarrhea, while numerically higher in each of the higher dulaglutide groups compared with the 1.5 mg group were similar between between the dulaglutide 3.0 mg and 4.5 mg groups in a clinical trial.*

Talk with your healthcare provider about any side effects you experience.

If you experience nausea, talk to your doctor. In the meantime, you may find the following tips helpful.

  • Eat smaller meals — try splitting your three daily meals into four or more smaller ones
  • Stop eating when you feel full
  • Avoid fried or fatty foods
  • Try eating bland foods like toast, crackers, or rice

*In studies, GI side effects were more common in people taking Trulicity than people taking placebo, and people taking Trulicity were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure). Trulicity may cause severe stomach problems.

Additional information as you're getting started

Trulicity is designed to fit into your busy life.

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Choosing your Trulicity day

Trulicity is taken just once a week. You can take Trulicity any time during this day, with or without meals. So, start by picking the best day for you and mark it as your Trulicity Day.

Do your best to stick to the same day every week.

If you'd like to change your Trulicity Day, you can. If it's been more than 3 days since your last dose, you can switch. If it's been fewer than 3 days since your last dose, wait until the following week to take the dose on your new Trulicity Day.

*Do not take 2 doses of Trulicity within 3 days of each other.

[The 4 Trulicity Pens]

More dose options. More treatment possibilities.

Trulicity has 4 dose options to better fit your type 2 diabetes needs. And because each dose comes in the easy-to-use* pen, you can continue to have the same experience with once-weekly Trulicity, regardless of the dose you’ve been prescribed.

*In a study, 94% of people said it was easy to use.

Read the Instructions for Use included with your pen.

Choosing your injection site

Your doctor can help you choose the areas on your body that are best to use Trulicity. Be sure to use a different spot every time and do not overuse any one. Suggested places to use Trulicity are your upper arm, abdomen, or thigh (see diagram below).

Injection Sites Illustration

How Trulicity can help

Starts acting from the first dose

Trulicity starts lowering your blood sugar from the first dose by helping your body release the insulin it’s still making.

Blood sugar levels

In studies, Trulicity has been proven to lower blood sugar levels. People taking Trulicity may notice better blood sugar numbers before eating in the morning (fasting blood sugar).

A1C reduction

Trulicity may offer lasting A1C improvements. In a study, some Trulicity users saw a significant improvement when their A1C was measured after 6 months, and it was still improved after they had been taking Trulicity for 1 year.

Majority of people reached an A1C under 7%.

  • Studies ranging between 24-36 weeks
  • 59% to 60% for 0.75 mg Trulicity
  • 50% to 68% for 1.5 mg Trulicity
  • 56% for 3.0 mg Trulicity
  • 62%for 4.5 mg Trulicity

If you have trouble meeting your A1C goal, talk with your doctor. You may need to adjust your medication, diet or exercise routine.

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Weight Change

Trulicity is not a weight loss drug. Individual results may vary. People lost up to 10 lbs. While many people in clinical trials lost weight, some did gain weight.

In one study, many people lost some weight over the course of 6 months, and they were able to keep if off for the remainder of the study.

In clinical trials, weight change in adults ranges from +0.4 lbs (0.75 mg) to -10.1 lbs (4.5 mg).

Hear from real Trulicity users


Storing your pen

  • Store your pen in the refrigerator, but do NOT freeze your pen.
  • If you decide to travel with your Trulicity pens, you can keep them at room temperature (below 86°F, 30°C) for up to 14 days.
[Icon of a house with thecopy: Trulicity Pen may be stored at room temp for 14 days]

Dispose safely after use

Even though there’s no need to handle or see the needle in your Trulicity Pen, it’s important to safely dispose of your Trulicity Pens in a sharps container. If you don't have a sharps container, be sure to dispose the Trulicity pen in a puncture-resistant container with a closable lid -- like an empty plastic laundry detergent bottle, or a coffee can.

Keep container out of reach from children and pets.

Refer to regulations in your area for how to dispose of the container properly.

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The Lilly Answers Center

If you have additional questions, call The Lilly Answers Center at 1‑844‑TRU‑INFO (1‑844‑878‑4636). Although we won't be able to replace the advice of your healthcare provider, we'll do our best to help you.

Purpose and Safety Summary 

Purpose and Safety Summary 

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