What to expect when starting Trulicity®

Watch a video on what to expect

In this video, Lucy will walk you through some of the changes and side effects you may experience when starting Trulicity. She'll offer tips on how you can manage some of these side effects, track how you're feeling, and set helpful reminders to take Trulicity. Please remember to review the Important Safety Information in the link below this video.


It is important to be aware of the potential changes and side effects that may occur when you start taking Trulicity. Remember to talk to your doctor about any changes that you experience. You can download the Trulicity Tracking Chart to record your blood sugar numbers, changes in weight, and how you’ve been feeling. Be sure to share your results with your healthcare provider during your next visit.

Benefits of Trulicity

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Blood sugar levels

In studies, Trulicity has been proven to lower blood sugar levels. People may notice a reduction in blood sugar before and after meals. In some studies, most people taking Trulicity noted better blood sugar numbers before eating in the morning (fasting blood sugar).

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A1C reduction

Trulicity may offer lasting A1C improvements. In a study, some Trulicity users saw a significant improvement when their A1C was measured after 6 months, and it was still improved after they had been taking Trulicity for 1 year. If you do not reach your A1C goal after 6 months, talk to your healthcare provider about adjusting your medications, diet, or exercise routine.

Possible side effects

The most common side effects with Trulicity tend to be mild to moderate. These may include nausea, diarrhea, vomiting, abdominal pain, decreased appetite, and indigestion.

In studies, gastrointestinal side effects were more common in people taking Trulicity than people taking placebo, and people taking Trulicity were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which may cause kidney problems (including kidney failure). Trulicity may cause severe stomach problems.

Trulicity may also cause serious side effects, including possible thyroid tumors (including cancer), inflammation of your pancreas, low blood sugar, or serious allergic reactions.

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Weight change

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Trulicity is not a weight loss drug, but some people may lose a little weight. In studies, people who lost weight lost 2 to 6 pounds on average. While many people in clinical trials lost weight, some did gain weight.

In one study, many people lost some weight over the course of 6 months, and they were able to keep if off for the remainder of the study.

Managing nausea

Everyone’s experience is different, but there are some changes that you might notice when you start to take Trulicity. In studies, some people (8%-29%) using Trulicity experienced nausea. For those who experienced nausea, it typically occurred at the beginning of treatment. Nausea generally subsided after the first 2 weeks. Some people experienced nausea with Trulicity beyond their second week of treatment. Less than 2% needed to stop taking Trulicity because of nausea.

If you experience nausea, talk with your healthcare provider. In the meantime, some people find the following tips may help:

  • Eat smaller meals—try splitting your three daily meals into four or more smaller ones
  • Stop eating when you feel full
  • Avoid fried or other fatty foods
  • Try eating bland foods like toast, crackers, or rice
  • Try foods or drinks containing ginger, like ginger tea
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