A reduction in both fasting and postprandial glucose was observed 48 hours after a single dose1

These data are from a pharmacodynamics study.

These data are from a pharmacodynamics study.

Fasting serum glucose (FSG) reductions occurred 48 hours after the first dose*1-3

These data are from a pharmacodynamics study.

Trulicity effect on fasting plasma glucose

*Study Description

Expand *Study Description
  • 6-week, multicenter, parallel-design, double-blind, part-randomized, placebo-controlled, multiple-dose, phase 1 study in patients ≥65 years old with type 2 diabetes treated with oral antihyperglycemic medications except sulfonylureas, disaccharidase inhibitors, and meglitinides
  • Study arms included placebo (n=8); Trulicity 0.5 mg (n=9), not a marketed dose; Trulicity 0.75 mg (n=11); and Trulicity 1.5 mg (n=9)
  • Primary objective was to evaluate the safety and tolerability of Trulicity 0.5 mg, 0.75 mg, and 1.5 mg for 6 weeks; mixed effect linear model; primary objective met
  • Data presented are LS mean change from baseline and are secondary endpoints

Postprandial serum glucose (PPG) reductions occurred 48 hours after the first dose*1,3,4

These data are from a pharmacodynamics study.

Trulicity effect on fasting plasma glucose

*Study Description

Expand *Study Description
  • 6-week, multicenter, parallel-design, double-blind, part-randomized, placebo-controlled, multiple-dose, phase 1 study in patients ≥65 years old with type 2 diabetes treated with oral antihyperglycemic medications except sulfonylureas, disaccharidase inhibitors, and meglitinides
  • Study arms included placebo (n=8); Trulicity 0.5 mg (n=9), not a marketed dose; Trulicity 0.75 mg (n=11); and Trulicity 1.5 mg (n=9)
  • Primary objective was to evaluate the safety and tolerability of Trulicity 0.5 mg, 0.75 mg, and 1.5 mg for 6 weeks; mixed effect linear model; primary objective met
  • Data presented are LS mean change from baseline and are secondary endpoints

Pharmacokinetics

Following once-weekly administration:

  • Steady state plasma concentrations were achieved between 2 and 4 weeks1
  • The time to maximum plasma concentration at steady state for Trulicity ranges from 24 to 72 hours, with a median of 48 hours1
  • Trulicity has a plasma half-life of approximately 5 days1
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