How you may feel

Everyone’s experience is different, but there are some changes that you may notice when you start taking Trulicity. From a change in blood sugar and A1C numbers to common side effects, the information below will help you understand what you can expect when you start Trulicity.

Everyone’s experience is different, but there are some changes that you may notice when you start taking Trulicity. From a change in blood sugar and A1C numbers to common side effects, the information below will help you understand what you can expect when you start Trulicity.

How can Trulicity benefit you

Blood sugar levels

In studies, Trulicity has been proven to lower blood sugar levels. People may notice a reduction in blood sugar before and after meals. In some studies, most people taking Trulicity noted better blood sugar numbers before eating in the morning (fasting blood sugar).

A1C reduction

Trulicity may offer lasting A1C improvements. In a study, some Trulicity users saw a significant improvement when their A1C was measured after 6 months, and it was still improved after they had been taking Trulicity for 1 year. If you do not reach your A1C goal after 6 months, talk to your healthcare provider about adjusting your medications, diet, or exercise routine.

Common side effects of Trulicity

Some people may experience nausea after starting on Trulicity. In studies, 8%-29% using Trulicity experienced some nausea, which typically occurred during the first 2-3 days after they took their first dose. Nausea generally subsides after the first 2 weeks, but some people experienced nausea with Trulicity beyond their second week of treatment. Less than 2% needed to stop taking Trulicity because of nausea.

The most common gastrointestinal side effects with Trulicity may include: nausea, diarrhea, vomiting, abdominal pain, decreased appetite, and indigestion.*

If you experience nausea, talk to your doctor. In the meantime, 
you may find the following tips helpful:

  • Eat smaller meals — try splitting your three daily meals into four or more smaller ones
  • Stop eating when you feel full
  • Avoid fried or fatty foods
  • Try eating bland foods like toast, crackers, or rice
  • Choose food or drinks containing ginger, like ginger tea

*In studies, GI side effects were more common in people taking Trulicity than people taking placebo, and people taking Trulicity were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure). Trulicity may cause severe stomach problems.

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Weight Change

Trulicity is not a weight loss drug, but some people may lose a little weight. In studies, people who lost weight lost 2 to 6 pounds on average. While many people in clinical trials lost weight, some did gain weight.

In one study, many people lost some weight over the course of 6 months, and they were able to keep if off for the remainder of the study.

Learn more about Trulicity by watching these videos

What to Expect

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Understand the basics—from picking your Trulicity Day to storing and disposing of your Trulicity Pen.

Getting Started

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How to handle nausea and other possible side effects.

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The Lilly Answers Center

If you have additional questions, call The Lilly Answers Center at 1‑844‑TRU‑INFO (1‑844‑878‑4636), Monday through Friday from 9 AM to 8 PM ET. Although we won't be able to replace the advice of your healthcare provider, we'll do our best to help you.

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Indication and Important Safety Information 
WARNING: POTENTIAL RISK OF THYROID TUMORS INCLUDING THYROID CANCER

Indication and Important Safety Information 
WARNING: POTENTIAL RISK OF THYROID TUMORS INCLUDING THYROID CANCER

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